Pati, Debasis and Kalva, Nagendra and Das, Soumen and Kumaraswamy, Guruswamy and Gupta, Sayam and Ambade, Ashutosh (2012) Multiple Topologies from Glycopolypeptide-Dendron Conjugate Self-Assembly: Nanorods, Micelles and Organogels. Journal of the American Chemical Society, 134 (18). pp. 7796-7802. ISSN 0002-7863

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ABSTRACT: Glycopolypeptides were synthesized by ring opening polymerization of glycosylated NCA monomer and attached to hydrophobic dendrons at one chain end by ‘click’ reaction to obtain amphiphilic anisotropic macromolecules. We show that by varying polypeptide chain length and dendron generation, organogel was obtained in DMSO while nanorods and micellar aggregates were observed in aqueous solutions. Assemblies in water were characterized by electron microscopy and dye encapsulation. Secondary structure of the glycopolypeptide chain was shown to affect the morphology whereas the chain length of poly(ethylene glycol) linker between glycopolypeptide and dendron did not alter rod-like assemblies. Bioactive surface chemistry of these assemblies displaying carbohydrate groups was demonstrated by interaction of mannose-functionalized nanorods with ConA.

Item Type: Article
Subjects: Polymer Science and Engineering
Depositing User: Nagendra Nagendra kalva
Date Deposited: 31 Jul 2014 11:52
Last Modified: 09 Mar 2015 06:13

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